AN UNBIASED VIEW OF LDN-27219 PROTEIN KINASE TARGETING

1 particularly interesting compound is LDN-27219. Though most tTG inhibitors are created to bind towards the protein crosslinking Lively website, LDN-27219 alternatively binds into the nucleotide binding pocket in the enzyme whilst it is in its closed-point out conformation, and stabilizes that conformation to avoid crosslinking activity.seventy ei